About project

Chronobiotics are drugs, both experimental and used in medical practice, constituting a rather heterogeneous, from a chemical point of view, group of substances that can modify the parameters of the circadian rhythm of fluctuations in various physiological and biochemical parameters, such as, for example, the expression of the “clock” genes themselves in organisms -models and cell cultures or the expression of clock-controlled genes. The class of chronobiotic drugs has been known for more than 50 years, since the properties of the hormone melatonin were discovered and described in detail in the clinic. Despite attempts to systematize chronobiotics, there is not yet a unified classification of these pharmacological agents (natural chrononutrients, synthetic targeted circadian rhythm modulators, hypnotics, chronobiotic hormones are identified), and there is no single source of knowledge about chronobiotics. Creating the world's first curated and updated database of chronobiotic drugs (circadian rhythm modulators) and organizing access to it through the Internet information and telecommunications network is an extremely urgent fundamental task of chronobiology, chronomedicine and pharmacoinformatics/bioinformatics.