|
|
CC(=CCC1=CC(=C(C=C1O)O)C(=O)/C=C/C2=CC=C(C=C2)O)C |
none |
|
RORA
,
RORα
|
ROR
|
|
|
|
C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O |
Not approved |
|
p38 MAP kinase
|
Inhibits p38 MAPK α/β isoforms
|
|
|
|
CCC(=O)NC1CC(C2=CC=CC=C2C1)C3=CC=CC=C3 |
not approved |
|
Melatonin receptor
|
antagonist of melatonin receptors
|
|
|
|
CC1=CC(=C(C=C1)C(C2=CC=CC=C2)NC(=O)CC3=CC4=C(C=C3)OC(=C4)C(C5=C(ON=C5C)C)O)C |
Not approved |
|
RORα
|
ROR
|
|
|
|
C1=CC(=C(C=C1/C=C/C(=O)O[C@@H](C(=O)O)[C@@H](OC(=O)/C=C/C2=CC(=C(C=C2)O)O)C(=O)O)O)O |
none |
|
PGC-1α
,
CLOCK-BMAL1
,
GSK-3α/β
|
PGC-1α interaction,
Core clock modulation,
Activation of CLOCK/Bmal1 mediated transcription,
Interferes with CLOCK–BMAL1,
Selective GSK-3β Inhibition:,
Circadian Clock Impact,
inhibits glycogen synthase kinase-3β (GSK-3β)
|
|
|
|
CC1=C(C=CC(=C1)S(=O)(=O)N2CCCCC2)OC |
Not approved |
|
Melanopsin (Opn4)
|
Competitive blockade of melanopsin’s retinal-binding site
|
|
|
|
CC(=O)NCCC1=CNC2=C1C=C(C=C2)NC(=O)OC |
not approved |
|
MT3
|
MT3 receptor ligand
|
|
|
|
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC |
Approved |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
mTOR signaling inhibition,
Serine/threonine-protein kinase mTOR
|
|
|
|
C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O |
None |
|
PER2 gene expression
|
BMAL1 expression modulation
|
|
|
|
CCC(=O)NCC1CC1C2=C3CCOC3=CC=C2 |
Approved |
|
Melatonin receptor
,
MT1
,
MT2
|
Melatonin receptor binding,
MT1 receptor binding,
MT2 receptor ligand
|
|
|
|
C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O |
Approved |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
,
Fe
|
Bmal1,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|
|
|
CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OCCCOC3=CC4=C(C=CC=C4CCNC(=O)C)C=C3 |
not approved |
|
Melatonin receptor
,
MT1
,
MT2
|
Melatonin receptor binding,
MT2 receptor antagonist,
MT1 receptor binding
|
|
|
|
CCNC(=O)CC[C@@H](C(=O)O)N |
none |
|
BMAL1 expression (induction)
|
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|
|
|
CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO |
Approved |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
|
Bmal1,
BMAL1 expression modulation,
BMAL1 expression modulation,
"Tyrosine-protein kinase ABL1, Lck, Yes, Fyn, BTK, CSK, Fgr, FRK, Lyn Proto-oncogene tyrosine-protein kinase Src Ephrin type-A
|
|
|
|
COC1=CC2=C(C=C1)NC=C2CCNC(=O)C3=CC(=O)C=CO3 |
Not approved |
|
Melatonin receptor
,
MT3
,
MT1
,
MT2
|
MT3 receptor ligand,
MT1 receptor binding,
MT2 receptor ligand
|
|
|
|
CC(C(=O)NCCC1CCC2=C1C3=C(C=C2)OCC3)O |
Not approved |
|
Melatonin receptor
,
MT1
,
MT2
|
Melatonin receptor binding,
MT1 receptor binding,
MT2 receptor ligand
|
|
|
|
CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC |
Approved |
|
CLOCK-BMAL1
|
BMAL1 expression modulation
|
|
|
|
C1=CC(=C(C=C1/C=C/C2=CC(=CC(=C2)O)O)O)O |
Not approved |
|
Per2 expression
,
Per 1 expression (gene)
|
PER gene exspression modulation
|
|
|
|
CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
DNA polymerase/reverse transcriptase (HBV-D) binding
|
|
|
|
[2H]C([2H])([2H])C(=O)NCCC1=CNC2=C1C=C(C=C2)OC |
Approved |
|
MT1
|
Melatonin receptor binding
|
|
|
|
CC(C(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3)O |
Approved |
|
Melatonin receptor
|
Melatonin agonist
|
|
|
|
CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
approved |
|
CLOCK-BMAL1
|
BMAL1 expression modulation
|
|
|
|
CCCC(=O)NCCC1=C2C=C(C=CC2=CN=N1)OC |
Not approved |
|
MT1
,
MT2
|
Melatonin receptor binding
|
|
|
|
C1=CC=C2C(=C1)C=CN2 |
not approved |
|
Melatonin receptor
|
Melatonin receptor binding
|
|
|
|
C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl |
approved |
|
CLOCK-BMAL1
|
Modulates sleep architecture via H1-histamine receptor antagonism
|
|