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List of Chronobiotics



Name SMILES FDA Status Effects Targets Mechanisms Articles
CC(C)(C)C(C)(C1CC23CCC1(C4C25CCN(C3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O Approved Mu opioid receptor , OPRK1 , OPRD1 opioid receptors binding
C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.[Br-] Approved Muscarinic acetilcholine receptror M1 Affects melatonin synthesis
CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O Approved Mu opioid receptor opioid receptors binding
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O Approved Mu opioid receptor , OPRK1 , OPRD1 Unknown, opioid receptors binding
CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C Not approved Mu opioid receptor , OPRK1 , OPRD1 opioid receptors binding
CC(CC1=CC=CC=C1)N Approved mPer2 , mPer1 , CLOCK-BMAL1 , Arntl (gene) Core clock modulation
C(OC(C(F)(F)F)C(F)(F)F)F Approved mPer2 , mPer1 , CRY1-PER2 complex Core clock modulation, Unknown
C(C(F)(F)F)(OC(F)F)F Not approved CRY1-PER2 complex Core clock modulation
C(C(F)(F)F)(OC(F)F)Cl Approved mPer2 , mPer1 , CRY1-PER2 complex Core clock modulation, Core clock suppression
CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3 Approved ADCY1 Adenylate cyclase binding activity affects circadian clock
C1CN(CC1O)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=CC6=CC=CC=C6C=C5 Not approved CLOCK-BMAL1 , SIRT1 SIRT1
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O Not approved CLOCK-BMAL1 Bmal1
C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl Not approved CLOCK-BMAL1 , SIRT1 Core clock modulation
CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC Not approved CLOCK-BMAL1 , RORα Bmal1
CC(=O)N1CCN(CC1)CC2=CC=C(C=C2)C3=CC=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O Not approved RORα ROR
CC1CC(CN(C1)C(=O)CC(C2=CC3=C(C=C2)OCO3)C4=C(C=C(C=C4OC)OC)O)C Not approved RORα ROR
C1CN(CCN1CC2=CC=C(C=C2)C3=C(C=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)F)CC4=CC=NC=C4 Not approved RORα ROR
CC1=C(SC(=N1)NC(=O)C)S(=O)(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O Not approved RORα ROR
C1=CSC(=C1)S(=O)(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O Not approved RORα ROR
TH301 Not approved CRY1-PER2 complex Selectively stabilizes CRY2
CC1=CC(=C(C=C1)N2C(=C3CSCC3=N2)NC(=O)C4=CC(=C(C=C4)C)C)C Not approved CRY1 Selective stabilizer of CRY1
C1CCC2=C(C1)C3=C(N=CN=C3S2)NC(=O)C4=CC=CC=C4Br Not approved CRY1 Selective stabilizer of CRY1
CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC(=C(C(=C2)Cl)C3=CC=CC=C3OC(F)(F)F)Cl Not approved RORα ROR
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC Approved CLOCK-BMAL1 Core clock modulation
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC Not approved CLOCK-BMAL1 HSP90 binding (in Arabidopsis)