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List of Chronobiotics



Name SMILES FDA Status Effects Targets Mechanisms Articles
CC(=O)NCCC1=C(NC2=C1C=C(C=C2)OC)C3=CC=CC=C3 not approved Melatonin receptor , MT1 , MT2 MT1 receptor binding, MT2 receptor ligand, Melatonin agonist
CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC.Cl approved Melatonin receptor Melatonin receptor binding
CC(=O)NCCC1=CNC2=CC=CC=C21 Not approved Melatonin receptor , MT1 Melatonin receptor binding, MT1 receptor binding
CC(=O)NCCC1=C2C=C(C=CC2=CC(=C1)O)O None MT1 , MT2 Melatonin receptor binding, MT1 receptor binding, MT2 receptor ligand
[2H]C([2H])(C1=CC=CC2=C1C=C(C=C2)OC)C([2H])([2H])NC(=O)C Not approved Melatonin receptor Melatonin receptor binding
[2H]C([2H])([2H])C(NC([2H])([2H])C([2H])([2H])C(C1=C2)=CNC1=CC=C2OC)=O not approved MT1 , MT2 Melatonin receptor binding, MT1 receptor binding, MT2 receptor ligand
[2H]C([2H])([2H])C([2H])([2H])C(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3 Approved Melatonin receptor Melatonin receptor binding
CCCCC(=O)NCCC1=C(NC2=CC=CC=C21)CC3=CC=CC=C3 Not approved Melatonin receptor Melatonin receptor binding
CC(=O)NCCN1CCC2=C1C3=C(C=C2)OCC3 Not approved Melatonin receptor , MT1 MT1 receptor binding
[2H]C([2H])([2H])CC(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3 Approved Melatonin receptor Melatonin receptor binding
CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)Cl Not approved Melatonin receptor Melatonin receptor binding
[2H]C([2H])([2H])C([2H])([2H])C(=O)NC[C@@H]1C[C@H]1C2=C3CCOC3=CC=C2 not approved Melatonin receptor Melatonin receptor binding
CC(=O)NCCC1=C(OC2=C1C=C(C=C2)OC)CC3=CC(=CC=C3)OC Not approved Melatonin receptor Melatonin receptor binding
CCCCCC1=CC(=C(C(=C1)O)CC=C(C)CCC=C(C)C)O Not approved Cannabinoid receptor Core clock modulation, Unknown
CCCCCC1=CC(=C2C3C=C(CCC3C(OC2=C1)(C)C)C)O Not approved Cannabinoid receptor Core clock modulation
CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O Not approved RORA , NR1D1 , RORB Disruption of circadian clock, Core clock modulation
CCCCCC1=CC(=C2C=CC(OC2=C1)(C)CCC=C(C)C)O Not approved Cannabinoid receptor Unknown
CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O Approved Mu opioid receptor , OPRK1 , OPRD1 Unknown, Kappa opioid receptor binding, delta opioid receptor binding
Hydrocodone Approved Mu opioid receptor , OPRK1 , OPRD1 Mu opioid receptor binding, Kappa opioid receptor binding, delta opioid receptor binding
CCCCCC1=CC(=C(C(=C1)O)C2=C(C=CC(=C2)C)C(=C)C)O Not approved Cannabinoid receptor , CB2 Disruption of circadian clock, Core clock modulation, Unknown, Cannabinoid receptor stimulation
CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O.CCCCCC1=CC(=C2C3C=C(CCC3C(OC2=C1)(C)C)C)O Not approved Cannabinoid receptor , CB2 Disruption of circadian clock, Core clock modulation, Unknown, Cannabinoid receptor stimulation
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4 Approved Mu opioid receptor , OPRK1 , OPRD1 Mu opioid receptor binding, Kappa opioid receptor binding, delta opioid receptor binding
CC1=CC(=CC(=C1)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=C(C=C3)OC Not approved. orexin receptor subtypes (OX1 and OX2) Orexin Receptor Blockade
CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Approved Mu opioid receptor , OPRK1 , OPRD1 , NMDA receptor , iGluRs Mu opioid receptor binding, Kappa opioid receptor binding, delta opioid receptor binding, opioid receptors binding
CN(C)CC1CCCCC1(C2=CC(=CC=C2)OC)O Approved Mu opioid receptor , OPRK1 , OPRD1 Mu opioid receptor binding, Kappa opioid receptor binding, delta opioid receptor binding, opioid receptors binding