|
|
C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N |
Approved |
|
Adenosine A1, A2A, A2B, and A3 Receptors
|
Activation of Adenosine Receptors
|
|
|
|
CCN(C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C#N)C(=O)C |
Approved |
|
GABAA receptors
|
GABA A receptor binding,
GABAergic system influence
|
|
|
|
C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O |
Not approved |
|
ROR gamma
|
PTEN,
ROCK,
p53
|
|
|
|
CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N |
Approved |
|
mPer2
,
mPer1
,
CRY1-PER2 complex
,
CRY1
,
CLOCK-BMAL1
|
Core clock suppression
|
|
|
|
CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O |
not approved |
|
Fe deficiency
|
Unknown
|
|
|
|
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)CNC(=O)N.C(=O)(C(F)(F)F)O |
none |
|
Neuropeptide Y Y1 receptor
|
Neuropeptide Y1 receptor binding
|
|
|
|
CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C |
Approved |
|
mPer2
,
mPer1
,
CRY1-PER2 complex
|
Core clock modulation
|
|
|
|
CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C |
Approved |
|
Microbiota
|
protect
|
|
|
|
CCOC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-] |
not approved |
|
mPer2
,
REV-ERBα
,
Per2 expression
|
Agonist REV-ERB alpha
|
|
|
|
C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4 |
Approved |
|
5-HT1A
|
Serotoninergic signaling
|
|
|
|
C1=CC=C2C(=C1)C3=C4C2=CC5=CC=CC6=C5C4=C(C=C6)C=C3 |
none |
|
CLOCK-BMAL1
|
Disruption of circadian clock,
aryl hydrocarbon receptor (AhR) binding
|
|
|
|
CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F |
Approved |
|
Calmodulin
|
Calmodulin binding (Neurospora)
|
|
|
|
CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC |
Not approved |
|
CLOCK-BMAL1
|
Antagonist of Rev-Erb nuclear receptors,
de-repressing BMAL1
|
|
|
|
C1=CC2=C3C(=C1)C4=CC=CC5=C4C6=C(C=C5)C=CC(=C36)C=C2 |
None |
|
mPer2
,
mPer1
,
CRY1-PER2 complex
,
CLOCK-BMAL1
|
Disruption of circadian clock,
Interferes with CLOCK–BMAL1,
aryl hydrocarbon receptor (AhR) binding
|
|
|
|
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31 |
Approved |
|
D2R (dopamine receptor)
|
Hypnotic effect,
Sleep promotion
|
|
|
|
CC1=C(OC2=C1C3=C(C=C2)OC(CC3=O)(C)C4=CC=C(C=C4)Cl)C(=O)N5CCC6=CC=CC=C65 |
Not approved |
|
CRY1
|
Binds CRY1 FAD-binding
|
|
|
|
C1=CC=C2C(=C1)C=CC3=CC4=C(C=CC5=CC=CC=C54)C=C32 |
none |
|
mPer2
,
mPer1
,
CRY1-PER2 complex
,
CLOCK-BMAL1
|
Disruption of circadian clock,
Bmal1,
Interferes with CLOCK–BMAL1,
aryl hydrocarbon receptor (AhR) binding
|
|
|
|
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F |
Approved |
|
D2R (dopamine receptor)
|
Dopamine receptor binding
|
|
|
|
C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl |
Not approved |
|
CK1δ
|
Inhibits CK1δ
|
|
|
|
C1=CC=C2C(=C1)C=CC3=C2C=CC4=CC=CC=C43 |
none |
|
mPer2
,
mPer1
,
CRY1-PER2 complex
,
CRY1
,
CLOCK-BMAL1
|
Disruption of circadian clock,
Bmal1,
modulation of nuclear receptor signaling pathways,
Interferes with CLOCK–BMAL1,
Targets BMAL1–CLOCK DNA-binding activity
|
|
|
|
C1CCC(C(C1)CN2CCN(CC2)C3=NSC4=CC=CC=C43)CN5C(=O)C6C7CCC(C7)C6C5=O |
Approved |
|
mPer2
,
mPer1
,
CRY1-PER2 complex
,
CRY1
,
CLOCK-BMAL1
,
Arntl (gene)
|
Core clock modulation
|
|
|
|
C1=CC=C2C=C3C4=CC=CC5=C4C(=CC=C5)C3=CC2=C1 |
none |
|
mPer2
,
mPer1
,
CRY1-PER2 complex
,
CRY1
,
CLOCK-BMAL1
|
Disruption of circadian clock,
Bmal1,
Interferes with CLOCK–BMAL1,
Targets BMAL1–CLOCK DNA-binding activity,
aryl hydrocarbon receptor (AhR) binding
|
|
|
|
C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO |
Approved |
|
Unknown
|
Unknown,
5-HT7 binding
|
|
|
|
CCCCCC1=CC(=C2C(=C1)OC(C3=C2C=C(C=C3)C)(C)C)O |
Not approved |
|
Cannabinoid receptor
,
CB2
|
Disruption of circadian clock,
Core clock modulation,
Unknown,
Cannabinoid receptor stimulation
|
|
|
|
CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3 |
Approved |
|
T58921 Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
,
BMAL1 expression (induction)
,
CLOCK gene expression
|
protect
|
|