|
|
CC1=[N+](C2=CC=CC=C2C(=C1)N)CCCCCCCCCC[N+]3=C(C=C(C4=CC=CC=C43)N)C.[Cl-].[Cl-] |
Approved |
|
CLOCK-BMAL1
|
Bmal1,
BMAL1 expression modulation
|
|
|
|
CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42 |
Approved |
|
5-HT7
|
5-HT7 binding
|
|
|
|
CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O |
Approved |
|
Histamine 1 receptor
|
Histamine 1 blocker
|
|
|
|
CC(C)(C)OC(=O)CC1=CC(=C(C=C1CC2=CC(=C(C=C2[125I])OC)OC)OC)OC |
None |
|
MT2
|
MT2 receptor ligand
|
|
|
|
ClC=1C=C(C=CC1Cl)N1C(NC2=C(C1=O)C=NN2C2=CC=CC=C2)=O |
none |
|
CCA1
|
PRR
|
|
|
|
(B. bifidum W23, B. lactis W51, B. lactis W52) and lactobacilli (L. acidophilus W22, L. casei W56, L. paracasei W20, L. plantarum W62, L. salivarius W24, L. lactis W19) |
Not approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
NPAS2
,
BMAL1 expression (induction)
,
TIMELESS
|
Core clock modulation,
Bmal1,
Activation of CLOCK/Bmal1 mediated transcription,
Circadian Clock Impact,
TIMELESS
|
|
|
|
C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F |
Approved |
|
mPer1
,
CRY1-PER2 complex
,
CRY1
,
CRY1
|
PER gene exspression modulation,
CRY gene expression modulation
|
|
|
|
CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2 |
Approved |
|
Histamine 1 receptor
|
Histamine 1 blocker
|
|
|
|
CCC1=NN2C=CC3=C(C2=C1CCNC(=O)C)CCO3 |
none |
|
MT1
|
MT1 receptor binding,
MT2 receptor ligand
|
|
|
|
C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42 |
Approved |
|
mPer2
,
mPer1
,
CLOCK-BMAL1
|
Core clock modulation,
Bmal1
|
|
|
|
C1C2=C(C3=C(C=CC=N3)NC1=O)NC4=C2C=C(C=C4) Br |
none |
|
GSK-3α/β
|
Highly selective, ATP-competitive inhibition of GSK-3 (both α and β isoforms),
GSK‑3 Inhibition,
Selective GSK-3β Inhibition:,
inhibits glycogen synthase kinase-3β (GSK-3β)
|
|
|
|
CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3 |
Approved |
|
GABAA receptors
|
GABAergic system influence
|
|
|
|
CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CCSC)NC=O |
Not approved |
|
FPR1
,
FPR2
|
FPR2 full agonist,
FPR1 full agonist
|
|
|
|
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
none |
|
Dec1 gene expression
|
Activation of activin receptor-like kinase (ALK),
by an immediate-early induction of Dec1
|
|
|
|
CC1=NC=C(N1CCO)[N+](=O)[O-] |
None |
|
Microbiota
|
Melatonin synthesis alteration
|
|
|
|
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
Approved |
|
Lanosterol 14-α-demethylase (fungal CYP51)
|
Inhibits the fungal enzyme lanosterol 14-α-demethylase (CYP51)
|
|
|
|
CCCC(=O)NCCC1=C2C3=CC=CC=C3CCCN2C4=C1C=C(C=C4)OC |
none |
|
Melatonin receptor
,
MT1
,
MT2
|
MT1 antagonist,
Melatonin receptor binding,
antagonist of melatonin receptors,
MT2 receptor antagonist,
MT1 receptor binding,
MT2 receptor ligand
|
|
|
|
[2H]C([2H])(C1=CNC2=C1C=C(C=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C(=O)OC)OC(=O)C)OC(=O)C)OC(=O)C)C([2H])([2H])NC(=O)C |
Not approved |
|
MT1
,
MT2
|
Melatonin receptor binding
|
|
|
|
C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4 |
Approved |
|
GABAA receptors
|
GABAergic system influence
|
|
|
|
C1=CC=C(C(=C1)C(=O)O)O |
none |
|
Unknown | Multiple plant targets
|
Plastoquinone interaction
|
|
|
|
CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O |
Approved |
|
Unknown
|
Central clock rescue via microbial community alteration
|
|
|
|
CC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F |
Not approved |
|
TRPV4 Channel
|
This inhibition of TRPV4-mediated signaling can affect downstream pathways involved in the regulation of the circadian clock.
|
|
|
|
CCC(C)C1(C(=O)NC(=O)NC1=O)CC |
Approved |
|
GABAA receptors
|
GABAergic system influence
|
|
|
|
C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O |
Approved |
|
REV-ERBα
|
Core clock suppression
|
|
|
|
CC(C)(C[C@H]1CN(C2=C(O1)C=CC(=C2)C3=CC(=CC(=C3)F)OC(F)F)S(=O)(=O)C4=CC=CC(=C4)C(F)(F)F)C(=O)O |
Not approved |
|
RORB
,
ROR gamma
|
ROR,
RORγ binding
|
|