|
|
CC(=O)NCCC1=C(NC2=C1C=C(C=C2)OC)CC3=CC=CC=C3 |
none |
|
MT2
|
MT2 receptor ligand
|
|
|
|
C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O |
Approved |
|
PER2 gene expression
|
Per2 expression alteration
|
|
|
|
CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OCCCCOC3=CC=C(C=C3)C4=CC=C(C=C4)C(=O)O |
Not approved |
|
MT1
|
selective MT1A receptor agonist
|
|
|
|
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O |
Not approved |
|
mPer2
,
mPer1
,
Per2 expression
,
Per 1 expression (gene)
,
Per 1 (Rat gene)
,
Per 2 (gene Rat)
|
PER gene exspression modulation
|
|
|
|
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C |
Approved |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
,
Vitamin D3 receptor
,
Vitamin D binding protein
|
Bmal1,
BMAL1 expression modulation,
BMAL1 expression modulation,
Vitamin D3 receptor, Homeobox protein Hox-A10, Vitamin D-binding protein
|
|
|
|
CC(C)CCC1=CC(=C2C=C(C=CC2=C1)OC)CCNC(=O)C |
none |
|
MT2
|
MT2 receptor agonist
|
|
|
|
C1CCC(CC1)(C2=CC=CC=C2)N3CCCCC3 |
Not approved |
|
NMDA receptor
,
NMDA receptor
|
Glutamate receptor ionotropic, NMDA 2B,
Glutamate receptor ionotropic, NMDA 3A antagonist,
Glutamate receptor ionotropic, NMDA 1,
NMDA receptor antagonist,
Glutamate receptor ionotropic, NMDA 2A,
USigma non-opioid intracellular receptor 1
|
|
|
|
CC1=CC(=C(C(=C1)C)N2CC(CC2=O)C(=O)N3CCC(CC3)(C4=CNC5=CC=CC=C45)C6=CNC7=CC=CC=C67)C |
none |
|
CRY1
|
CRY1 stabilizer,
binds CRY1 ubiquitination site,
Selective stabilizer of CRY1
|
|
|
|
CC1=CC=CC2=C1N=C(CN3C[C@H]4C[C@@H](C3)C5=CC=CC(=O)N5C4)N=C2NC6=CC=C7C(=C6)OCO7 |
none |
|
CRY1
,
CRY2
|
Selective stabilizer of CRY1,
Selectively stabilizes CRY2,
CRY 2 Stabilizer
|
|
|
|
CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4 |
Not approved |
|
mPer2
,
mPer1
,
Per2 expression
|
Lenghthen the circadian period,
PER gene exspression modulation
|
|
|
|
CCC(=O)NCCCC1=C(C=CC(=C1)OC)CC2=CC(=CC=C2)OC |
none |
|
MT2
|
MT2 receptor ligand
|
|
|
|
CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)OC)O4)O |
Approved |
|
Mu opioid receptor
,
OPRK1
|
Mu opioid receptor binding
|
|
|
|
CCCC(=O)NCCC1=C2C3=CC=CC=C3CN2C4=C1C=C(C=C4)OC |
none |
|
MT2
|
Melatonin receptor binding,
MT2 receptor ligand
|
|
|
|
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O |
Approved |
|
HCN2
,
HCN1
,
CNGA2
,
CNGA3
|
HCN2 activation,
HCN1 activator,
CNGA2 activation,
Affects melatonin synthesis,
CNGA3 activation,
OATP4C1 transportation
|
|
|
|
CC1=C(N=C(N=C1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O |
Approved |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
,
Dec1 gene expression
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
by an immediate-early induction of Dec1
|
|
|
|
CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3 |
Approved |
|
Mu opioid receptor
,
OPRK1
,
OPRD1
|
Mu opioid receptor binding,
Kappa opioid receptor binding,
delta opioid receptor binding
|
|
|
|
CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O |
Approved |
|
Corticosteroid hormone receptor
|
Affects melatonin synthesis,
Melatonin synthesis alteration,
Corticosteroid Hormone Receptor Agonist,
Glucocorticoid Signaling
|
|
|
|
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC |
Approved |
|
CLOCK-BMAL1
|
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
mTOR signaling inhibition
|
|
|
|
CC(C)C1=C(C(=CC=C1)C(C)C)O |
Approved |
|
GABAA receptors
|
GABA A receptor binding
|
|
|
|
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C |
Approved |
|
Corticosteroid hormone receptor
|
Corticosteroid Hormone Receptor Agonist,
Glucocorticoid Signaling
|
|
|
|
CNC1(CCCCC1=O)C2=CC=CC=C2Cl |
Approved |
|
CLOCK-BMAL1
|
Core clock modulation
|
|
|
|
CN1CCN(CC1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl |
Approved |
|
Unknown
|
Sleep promotion
|
|
|
|
CC(=O)NCCC1=C(CC2=C1C3=C(C=C2)OCC3)CC4CCCCC4 |
Not approved |
|
MT2
|
MT2 receptor agonist,
MT2 receptor ligand
|
|
|
|
CC1=CC(=C2C=C(C=C(C2=N1)F)F)NC(=O)NC3=CC=C(C=C3)N(C)C |
Not approved |
|
orexin receptor subtypes (OX1 and OX2)
|
OX₁R Antagonism
|
|
|
|
COC1=CC2=C(C=CC=C2CCNC(=O)C(F)F)C=C1 |
Not approved |
|
MT1
|
MT1 receptor binding
|
|