|
|
CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
,
Progesterone receptor
,
Estrogen receptor alpha
|
Bmal1,
BMAL1 expression modulation,
BMAL1 expression modulation,
Progesterone receptor, Estrogen receptor alpha, Mineralocorticoid receptor, Steroid 17-alpha-hydroxylase/17,20 lyase Kappa-typ
|
|
|
|
CN1C=NC2=C1C(=O)N(C(=O)N2C)C |
Approved as food (400 mg per day) |
|
Adenosine A1, A2A, A2B, and A3 Receptors
|
Activation of Adenosine Receptors,
Adenosine Monophosphate-Activated Protein Kinase (AMPK),
adenosine receptor binding
|
|
|
|
CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC |
Approved |
|
TRPV1
|
TRPV1 capsaicin site binding
|
|
|
|
C[C@@H](CC1=CC=CC=C1)NC |
Approved |
|
SLC6A2
|
methamphetamine-sensitive circadian oscillator (MASCO),
Monoamine transporter inhibitor,
increase dopamine signalling,
Non-canonical circadian genes
|
|
|
|
CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|
|
|
CC(CNC(=O)C)C1=CNC2=CC(=C(C=C21)OC)Cl |
Not approved |
|
Melatonin receptor
,
MT1
,
MT2
|
Melatonin receptor binding,
MT1 receptor binding,
MT2 receptor ligand
|
|
|
|
COC1=CC(=C(C=C1Cl)S(=O)(=O)N2CCCCC2)Cl |
Not approved |
|
Melanopsin (Opn4)
|
Photoreception inhibition,
Competitive binding at melanopsin’s retinal-binding site
|
|
|
|
COC1=C(C(=CC=C1)OCCCN)C2=CC(=NN2)NC3=NC=C(N=C3)C#N |
Approved |
|
CKI delta
|
CHK1 inhibitor crosstalk with caseine kinase 1,
CK1 Inhibition,
Chk1/2 inhibition,
PER2 phosphorylation
|
|
|
|
CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|
|
|
C1CC(C1)C(=O)NCCC2=CC=CC3=CC=CC=C32 |
Not approved |
|
Melatonin receptor
|
antagonist of melatonin receptors
|
|
|
|
CC(=O)NCCC1=CNC2=C1C=C(C=C2)OCCO |
none |
|
MT1
,
MT2
|
MT2 receptor antagonist,
MT1 receptor binding,
MT2 receptor ligand
|
|
|
|
CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
Bmal1,
BMAL1 expression modulation,
BMAL1 expression modulation,
Tubulin alpha-1A, beta, delta, gamma-1, epsilon chain Transcription factor AP-1 binding
|
|
|
|
CC(NCCC1=C2C=C(OC)C=CC2=CC=C1)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O |
Not approved |
|
Melatonin receptor
|
Melatonin receptor binding
|
|
|
|
CC(=O)NCCC1=C(NC2=C1C=C(C=C2)OC)CN3CCC4=CC=CC=C43 |
none |
|
MT2
|
MT2 receptor antagonist
|
|
|
|
CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](CO)O)O)O |
Approved |
|
PER2 gene expression
|
Restores oscillations of circadian genes
|
|
|
|
CC(C1CC1)N2C=NC3=C(N=C(N=C32)NCCN(C)C)NCC4=CC(=CC=C4)C(F)(F)F |
Not approved |
|
CKI delta
|
Inhibits casein kinase 1 delta (CKIδ) activity,
Inhibits CKIδ
|
|
|
|
O=C1NC2=C(C=CC=C2)/C1=C\C3=C(OC)C=C(OC)C=C3OC |
None |
|
CK1 epsilon
|
Targets CK1 epsilon
|
|
|
|
CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C |
Approved |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|
|
|
CC(=O)NCCN1C2=CC(=C(C=C2N=C1OC)Cl)OC |
not approved |
|
Melatonin receptor
|
Melatonin receptor binding
|
|
|
|
CC(=O)N/C=C/C1=C(C=CC2=C1C=C(C=C2)OC)OC |
none |
|
MT1
|
MT1 receptor binding
|
|
|
|
CC(CC1=CC2=C(C=C1)OCO2)NC |
Not approved |
|
SLC18A2
,
HTR2C
,
SLC6A3
,
SLC6A2
,
HTR2A
,
SLC6A4
,
HTR2B
|
Synaptic vesicular amine transporter interaction,
5-hydroxytryptamine receptor 2C binding,
Sodium-dependent dopamine transporter binding,
Sodium-dependent noradrenaline transporter,
5-hydroxytryptamine receptor 2A binding,
Sodium-dependent serotonin transporter,
5-hydroxytryptamine receptor 2B binding
|
|
|
|
C1=CC(=C(C=C1C(=O)O)O)O |
none |
|
RORA
,
RORα
|
Core clock modulation,
ROR
|
|
|
|
CCC1=C2C=COC2=C(OCC(F)CO)C=C1 |
none |
|
CLOCK-BMAL1
,
BMAL1
|
Bmal1,
Interferes with CLOCK–BMAL1,
Targets BMAL1–CLOCK DNA-binding activity
|
|
|
|
CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl |
Approved |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
|
BMAL1 expression modulation,
BMAL1 expression modulation,
Binding Androgen receptor, 17-hydroxylase, Steroid 21-hydroxylase, 11-hydroxylase, Cytochrome P450 19A1, Potassium voltage-
|
|
|
|
C1=CC=C2C(=C1)C3=NN(C4=CC=CC(=C43)C2=O)CCO |
None |
|
JNK
|
JNK kinase mediated circadian rhythm modulation
|
|