|
|
C1=CC2=C(C=C1F)C3=C(C=CC(=C3)F)N2CC(CN4CCNC4=O)O |
None |
|
CRY2
,
Mouse CRY2 with shp656
|
Selectively stabilizes CRY2
|
|
|
|
CN1[C@@H]2CC(C[C@H]1[C@H]3[C@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4 |
Approved |
|
Muscarinic acetilcholine receptror M1
|
Affects melatonin synthesis,
Muscarinic receptor binding
|
|
|
|
COC1=C(C=CC(=C1)C(=O)O)O |
Not approved |
|
MTOR (Human)
,
AMPK
,
JAC (Janus kinase)
|
mTOR signaling inhibition,
Serine/threonine-protein kinase mTOR,
AMPK-PP2A axis suppresses mTOR, advancing circadian phase in muscle.,
Adenosine Monophosphate-Activated Protein Kinase (AMPK),
Nuclear Factor Kappa B (NF- κB),
Janus kinase (JAK)/signal transducer and activator of transcription (STAT),
Nod-like receptor family protein (NLRP),
Toll-like receptors (TLRs),
Mitogen-Activated Signaling Proteins (MAPK),
Mammalian Target of Rapamycin (mTOR) signaling pathway
|
|
|
|
C1 =CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O)C(F)(F)F |
none |
|
BMAL1 expression (induction)
|
BMAL1 expression modulation,
p53 stabilization and apoptosis induction
|
|
|
|
COC1=C(C=C(C(=C1)/C=N\N2C(=NN=C2SC)C3=CC=CC=C3)Br)O |
not approved |
|
CK2 alpha
|
CK2 inhibition
|
|
|
|
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC |
none |
|
HSP90
|
HSP90 Binding,
HSP90-mediated BMAL1 modulation
|
|
|
|
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O |
none |
|
Per2 expression
|
protect,
PER gene exspression modulation,
caspase, Bax, TNF-α, and NF-MB,
Antioxidant
|
|
|
|
C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O |
none |
|
REV-ERBα
|
Agonist REV-ERB alpha
|
|
|
|
CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)OC |
Not approved |
|
CLOCK-BMAL1
|
Bmal1,
BMAL1 expression modulation,
Interferes with CLOCK–BMAL1
|
|
|
|
C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O |
none |
|
Serotonin N-acetyltransferase
|
inhibition of serotonin N-acetyltransferase
|
|
|
|
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O |
none |
|
RORA
,
RORα
|
ROR
|
|
|
|
COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O |
none |
|
Per2 expression
|
Per2 expression induction
|
|
|
|
C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O |
none |
|
CLOCK-BMAL1
,
BMAL1
,
CLOCK-BMAL1 COMPLEX
|
Bmal1,
Interferes with CLOCK–BMAL1
|
|
|
|
CC12CCC(=O)C=C1C3CC3C4C2CCC5(C4C6CC6C57CCC(=O)O7)C |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
Mineral corticoid receptor binding
|
|
|
|
C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O |
none |
|
GSK-3α/β
|
Highly selective, ATP-competitive inhibition of GSK-3 (both α and β isoforms),
GSK‑3 Inhibition,
Selective GSK-3β Inhibition:,
inhibits glycogen synthase kinase-3β (GSK-3β)
|
|