|
|
CC(C)N1C=NC2=C(N=CN=C21)NCC3=CC(=CC=C3)C(F)(F)F |
none |
|
CKI delta
|
Inhibits casein kinase 1 delta (CKIδ) activity
|
|
|
|
Unknown |
None |
|
GUT MICROBIOTA
|
Unknown metabolites
|
|
|
|
C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=O |
none |
|
GSK-3α/β
|
Highly selective, ATP-competitive inhibition of GSK-3 (both α and β isoforms),
Dual inhibitor of Cyclin-dependent kinases (CDK) and Glycogen Synthase Kinase-3 (GSK-3),
GSK‑3 Inhibition,
Selective GSK-3β Inhibition:,
inhibits glycogen synthase kinase-3β (GSK-3β)
|
|
|
|
C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl. Cl |
None |
|
CKI delta
|
Inhibits CK1δ,
Inhibits casein kinase 1 delta (CKIδ) activity,
Non-specific kinase inhibitor
|
|
|
|
[Li+].[Li+].C(=O)([O-])[O-] |
Approved |
|
mPer2
,
mPer1
,
CRY1-PER2 complex
,
CRY1
,
CRY1
,
Per2 expression
|
inhibits glycogen synthase kinase-3β (GSK-3β)
|
|
|
|
CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F |
None |
|
p38 kinase
|
Core clock modulation,
p38 signaling
|
|
|
|
COC1=C(N=CC(=C1OC)N2C(=O)N(C3=C(S2(=O)=O)C=CC=N3)CC4=C(C=C(C=C4F)F)F |
Not approved |
|
orexin receptor subtypes (OX1 and OX2)
|
Dopamine receptor antagonist,
Orexin Receptor Antagonism
|
|
|
|
C[C@@H]1CC(=O)C=C([C@]12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC |
Approved |
|
CLOCK-BMAL1
,
Heme
|
Core clock modulation,
Affects heme,
Affects heme biosynthesis
|
|
|
|
C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O |
Not approved |
|
Arntl (gene)
,
BMAL1 expression (induction)
,
Per2 expression
,
GUT MICROBIOTA
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
Activation of CLOCK/Bmal1 mediated transcription
|
|
|
|
Lactobacillus delbrueckii |
none |
|
GUT MICROBIOTA
|
protect,
Circadian Clock Impact,
Unknown metabolites
|
|
|
|
CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC43C)F)O |
Approved |
|
Corticosteroid hormone receptor
|
Core clock modulation,
Affects "Circadian rhtyhm signaling",
Calcium signaling,
Glutamat receptor signaling,
Corticosteroid Hormone Receptor Agonist
|
|
|
|
COC(=O)N1CCC[C@@H]([C@@H]1COC2CCC(CC2)C3=CC=CC=C3)NS(=O)(=O)C |
Not approved |
|
orexin receptor subtypes (OX1 and OX2)
|
OX₂R Activation
|
|
|
|
CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4 |
Not approved |
|
orexin receptor subtypes (OX1 and OX2)
|
OX₁R Antagonism
|
|
|
|
C[C@H]1CC[C@H](N(C1)C(=O)C2=C(C(=CC=C2)F)OC)CNC3=NC=C(C=C3)Br |
Not approved |
|
orexin receptor subtypes (OX1 and OX2)
|
OX₁ Receptor Blockade
|
|
|
|
Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1 |
None |
|
MT1
|
MT1 receptor binding
|
|
|
|
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O |
Approved |
|
Corticosteroid hormone receptor
|
Glucocorticoid Signaling,
Glucocorticoid receptors
|
|
|
|
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O |
Approved |
|
mPer2
,
mPer1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
PER gene exspression modulation,
BMAL1 expression modulation,
BMAL1 expression modulation,
Activation of CLOCK/Bmal1 mediated transcription,
influences HPA axis
|
|
|
|
C1=CC(=C2C(=C1)C=CO2)OCCCO |
none |
|
CLOCK-BMAL1
,
BMAL1
|
Bmal1,
Activation of CLOCK/Bmal1 mediated transcription,
Interferes with CLOCK–BMAL1,
Targets BMAL1–CLOCK DNA-binding activity
|
|
|
|
CN1C2=C(C(=O)N(C1=O)C)NC=N2 |
Approved |
|
PI3K/Akt
,
NF-kB
|
Nuclear Factor Kappa B (NF- κB),
cAMP signaling cascade,
Modulation of PI3K/Akt
|
|
|
|
CN(C)CCC1=CNC2=C1C(=CC=C2)O |
Not approved |
|
5-HT 2A R
|
Serotoninergic signaling,
Dopamine receptor binding
|
|
|
|
CCC1=C2C=COC2=C(OCCCO)C=C1 |
none |
|
CLOCK-BMAL1
,
BMAL1
|
Core clock modulation,
Bmal1
|
|
|
|
CC1(C)CC2=C(CO)C3=C(COC3=O)C(=C2C1)O |
None |
|
mPer2
,
Per2 expression
|
Core clock modulation,
Binding with factors affine to Period2 gene promoter
|
|
|
|
COC1=C(C=CC(=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)O)OC)O)O |
none |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
|
Core clock modulation,
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
Activation of CLOCK/Bmal1 mediated transcription
|
|
|
|
C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N |
Approved |
|
DAT ( human Dopamine transporter)
|
DAT interaction (human dopamine transporter)
|
|
|
|
C1=CC2=C(C=C1F)C3=C(C=CC(=C3)F)N2C[C@H](CN4CCNC4=O)O |
none |
|
CRY2
,
Mouse CRY2 with shp656
|
Selectively stabilizes CRY2
|
|