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List of Chronobiotics



Name SMILES FDA Status Effects Targets Mechanisms Articles
CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C Approved BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, 1,4-dihydropyridine calcium channel blocker
C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) BMAL1 expression modulation
C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, BMAL1 expression modulation, BMAL1 expression modulation
C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)F)Cl)N Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, BMAL1 expression modulation, BMAL1 expression modulation
[O-2].[O-2].[O-2].[As+3].[As+3] None CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, "Inhibitor of nuclear factor kappa-B kinase subunit beta Thioredoxin reductase 1, cytoplasmic Transcription factor AP-1 G1/S-
CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O.CS(=O)(=O)O Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, HIV-1 protease binding
C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-] Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, BMAL1 expression modulation, BMAL1 expression modulation, Intermediate conductance calcium-activated potassium channel, protein 4 Nuclear receptor subfamily 1 group I member 2, 3
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O Approved CLOCK-BMAL1 , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation
CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl Approved CLOCK-BMAL1 , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, calcimimetic and a P450 inhibitor
C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O Not approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, BMAL1 expression modulation, BMAL1 expression modulation
C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl Approved CLOCK-BMAL1 , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, DNA DNA topoisomerase 2-alpha, beta binding, targeting DNA and DNA topoisomerase 2-alpha.
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N Not approved GSK-3α/β Highly selective, ATP-competitive inhibition of GSK-3 (both α and β isoforms)
C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) , Beta 1,2 adrenergic receptor Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, Beta-1, 2 adrenergic receptor binding
CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl Approved CLOCK-BMAL1 , Arntl (gene) , Histamine 1 receptor , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, Histamine 1 blocker, BMAL1 expression modulation, Histamine H1 receptor, Nuclear receptor subfamily 1 group I member 3
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) , Retinoic acid receptor alpha Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, Binding retinoic acid receptor alpha
CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl Approved CLOCK-BMAL1 , BMAL1 expression (induction) , Topoisomerase I Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, inhibits topoisomerase I
C1CN1P(=S)(N2CC2)N3CC3 Not approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, DNA alkylation
CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3[N-]2)OCCCOC.[Na+] Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) , H+ K+ ATPase Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, Potassium-transporting ATPase alpha chain 1 binding activity
CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) , Retinoic acid receptor alpha Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation
COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) Bmal1, de-repressing BMAL1, BMAL1 expression modulation, BMAL1 expression modulation, DNA DNA topoisomerase 2-alpha, beta binding, Tubulin alpha-4A, beta chain binding
CC[C@@H]1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@@H]([C@@H](C4)OC)Cl)/C)O)C)OC)OC)C)\C Approved CLOCK-BMAL1 , Arntl (gene) , BMAL1 expression (induction) BMAL1 expression modulation, BMAL1 expression modulation, Calcineurin Inhibitor Immunosuppressant
CC1(CCC2=C3C(=C(C=C2O1)OCC(=O)NC4=CC=CC=C4C(=O)N)C(=CC(=O)O3)C5=CC=CC=C5)C Not approved CLOCK-BMAL1 Interferes with CLOCK–BMAL1
C1C2=C(C3=C(C=CC=N3)NC1=O)NC4=C2C=C(C=C4)Br Not approved GSK-3α/β Dual inhibitor of Cyclin-dependent kinases (CDK) and Glycogen Synthase Kinase-3 (GSK-3)
CS(=O)(=O)N(CC1=CC=CO1)CC(CN2C3=CC=CC=C3C4=CC=CC=C42)O Not approved CRY1-PER2 complex , CRY1 , CRY1 Selective stabilizer of CRY1, Selectively stabilizes CRY2, Binds CRY1 FAD-binding