|
|
CC1=C(C=CC2=C1N=C(N2)[C@@]3(CCCN3C(=O)C4=C(C=CC(=C4)OC)N5N=CC=N5)C)Cl |
Approved |
|
Orexin Receptors OX1R and OX2R
|
Orexin Receptor Antagonism
|
|
|
|
C[C@]1(C2=C(CC(CC2=O)(C)C)NC3=NNC(=C31)C(F)(F)F)C4=CC=CC=C4 |
Not approved |
|
GSK-3α/β
|
Selective GSK-3β Inhibition:,
Circadian Clock Impact
|
|
|
|
C1C(=S)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CC(F)(F)F |
Approved |
|
GABAA receptors
|
GABAergic system influence
|
|
|
|
C(C(Cl)(Cl)Cl)(O)O |
Not approved |
|
GABAA receptors
|
GABAergic system influence
|
|
|
|
C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)O)N |
Not approved |
|
ADORA2B
|
A2B receptor agonist.
|
|
|
|
CN1CCN(CC1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4) Cl |
Approved |
|
GABAA receptors
|
GABA A receptor binding,
GABAergic system influence
|
|
|
|
CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl |
Approved |
|
GABAA receptors
|
GABA A receptor binding,
GABAergic system influence
|
|
|
|
CCCC(C)C1(C(=O)NC(=O)NC1=O)CC=C |
None |
|
GABAA receptors
|
GABA A receptor binding,
GABAergic system influence
|
|
|
|
CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4Cl |
Approved |
|
GABAA receptors
|
GABA A receptor binding,
GABAergic system influence
|
|
|
|
CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F |
Approved |
|
GABAA receptors
|
GABAergic system influence
|
|
|
|
CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C=C)C)C(=C4CCC(=O)O)C)C(=C3C)CCC(=O)O)C=C |
None |
|
CLOCK-BMAL1
|
Core clock modulation,
BMAL1 expression modulation
|
|
|
|
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-] |
Not approved |
|
CLOCK-BMAL1
,
REV-ERBα
,
Rev-erb expression
,
NLRP3 inflammasome
|
BMAL1 expression modulation,
Rev-erb expression modulation,
NLRP3 inflammasome binding
|
|
|
|
CN1CCN(CC1)/C=C\2/C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl |
Not approved |
|
GABAA receptors
|
GABA A receptor binding,
GABAergic system influence
|
|
|
|
C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3 |
Not approved |
|
GABAA receptors
|
GABA A receptor binding,
GABAergic system influence
|
|
|
|
CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl |
Not approved |
|
GABAA receptors
|
GABA A receptor binding,
GABAergic system influence
|
|
|
|
C1=CC2=C(C=CC(=C2N=C1)O)[N+](=O)[O-] |
Approved |
|
BMAL1 expression (induction)
|
BMAL1 expression modulation
|
|
|
|
CN(CCCOC1=C(C=C(C=C1)Cl)Cl)CC#C.Cl |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
,
Monoamine oxidase A
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
Monoamine oxidase A binding
|
|
|
|
CN1CC(CC2C1CC3=CN(C4=CC=CC2=C34)C)CNC(=O)OCC5=CC=CC=C5 |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|
|
|
CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O |
Approved |
|
CLOCK-BMAL1
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|
|
|
C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
BMAL1 expression modulation,
Myosin-9 binding
|
|
|
|
CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O |
Approved |
|
CLOCK-BMAL1
,
BMAL1 expression (induction)
,
Glyceraldehyde-3-phosphate dehydrogenase
|
Glyceraldehyde-3-phosphate dehydrogenase
|
|
|
|
C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)O)C |
Approved |
|
BMAL1 expression (induction)
|
BMAL1 expression modulation,
"Peptidyl-prolyl cis-trans isomerase A Peroxiredoxin-1 60S ribosomal protein L10, L14, L18, L23a, L35, L4 40S ribosomal prote
|
|
|
|
CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
Bmal1,
de-repressing BMAL1,
BMAL1 expression modulation,
BMAL1 expression modulation,
DNA DNA topoisomerase 2-alpha, beta binding
|
|
|
|
CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C)C)C)OC |
Approved |
|
CLOCK-BMAL1
,
Arntl (gene)
,
BMAL1 expression (induction)
|
Bmal1,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|
|
|
CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O |
Approved |
|
CLOCK-BMAL1
,
D2R (dopamine receptor)
,
BMAL1 expression (induction)
|
Dopamine receptor binding,
Bmal1,
de-repressing BMAL1,
Dopamine receptor binding,
Dopamine receptor agonist,
BMAL1 expression modulation,
BMAL1 expression modulation
|
|